Work at the translation layer between biology and decisions.

We’re driven to help patients. If you are too, help us bring them better medicines.

WHY 5PRIME

Science that directly changes what happens.

We are a small team of specialists doing technically sophisticated work on problems that matter. The decisions our evidence informs are real: capital allocated, programs advanced, and trials avoided.

If you want your scientific work to move from results to action, and to that at the frontier of human genetics, AI and drug development, this is the right environment.

Direct connection between science and impact

Our outputs inform decisions at major pharmaceutical companies and early-stage biotechs. The chain between your analysis and its consequence is short and visible.

Technical depth at the frontier

We work with large-scale multi-omics data, develop novel AI and statistical analytical methods, and deploy them to answer specific
questions that standard workflows cannot address.

A field-leading scientific foundation

The founding team has 240+ peer-reviewed publications and developed methods foundational to how the field approaches causal gene identification and target validation.

Montréal, a serious scientific city with a great joie-de-vivre

McGill, the Montreal Neurological Institute, and a substantial biotech sector. Hybrid and remote options available across Canada, with relocation support for the right candidates.

OUR CULTURE

The evidence is only as good as the team that generates it.

Collaboration

The best evidence comes from people who ask the right questions together. We share what we know and build on each other's work.

Honesty

We tell partners when the evidence doesn't support their program. The same directness applies internally. Difficult conversations happen early, not late.

Accountability

Our work informs decisions that carry real consequences for patients and capital. We own that: the quality of the evidence, and what it says.

Excellence

We hold ourselves to the standard of evidence that could be trusted at a board-level decision. Not because it's expected. Because that's the point.

OPEN ROLES

We are hiring at the core of our science team.

Location and working arrangements

These positions are available for hybrid work in Montréal or remote within Canada. We give preference to candidates in Montréal or Québec, or those willing to relocate.

Relocation and immigration support is available for candidates interested in working in Montréal.

MONTRÉAL, QC · HYBRID OR REMOTE (CANADA)

Core Science

Genetic Epidemiologist / Statistical Geneticist

The analytical heart of 5Prime's work. You will apply Mendelian randomization, GWAS, and multi-omics methods to answer specific drug development questions: target validation, safety profiling, biomarker identification, patient stratification. The questions are real, the datasets are large, and the outputs go directly into partner decisions.

Not seeing the right role?‍

We occasionally recruit outside of posted openings when the fit is strong. If you work in statistical genetics, computational biology, or biostatistics and are interested in applying human genetics to drug development decisions, send us your CV and cover letter to: careers@5primesciences.com.

Questions about a role or the team?