Founded on science that helped define the field.
The best medicines demand the best causal human biology evidence.
5Prime generates it.
OUR ORIGIN
Built from McGill. Operating globally.
2021
Founded. Spun out of McGill University's Richards Lab
15+
experts in genomics, biostatistics, and computational biology
240+
peer-reviewed publications from the founding team
Led by a clinician-scientist,
the 5PS team uses AI, genetics, data science and medicine to find better drug targets
Advisory Board
PUBLICATIONS & RESEARCH
Science that speaks for itself.
Peer-reviewed publications and presentations
01
Genetic Therapies and Precision Medicine
Sadler M. et al.
ASG 2025
Poster
01
Human genetics evidence supporting ANGPTL4 inhibition to reduce remnant cholesterol and triglycerides informs successful Phase 2a trial outcomes
Bhatnagar S et al.
ASHG Annual Meeting · 2025
Platform presentation
01
Trajecta: Identifying genetic determinants of disease progression distinct from susceptibility
Tudball M. et al.
ASHG Annual Meeting · 2025
Poster
01
Proteogenomic Mendelian randomization for causal target and biomarker identification
01
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Chen Y et al.
Nature Genetics · 2023
Peer-reviewed article
01
An Atlas of Human and Murine Genetic Influences on Osteoporosis
Morris JA et al.
Nature Genetics
Peer-reviewed article
01
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
Zheng HF et al.
Nature · 2015
Peer-reviewed article
01
Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization
Skrivankova VW et al.
JAMA · 2021
Peer-reviewed article
OUR VALUES
What guides us.
01
AI-driven causal human biology evidence, over associations, animal and cellular models.
Not all evidence is decision-grade. We are rigorous about the distinction between causation and correlation, and honest about what the evidence cannot tell you. When the evidence refutes a hypothesis, we say so with the same rigour as when it confirms one.
02
Translation over reporting
The value of human evidence is not what it reveals. It is what it helps teams decide. Our goal is clarity at decision points, not messy data dumps.
03
Earlier over later
The biggest losses in drug development begin with biology decisions made early in pipeline. We work at the front end of value creation, where evidence has the most downstream impact.
OUR CULTURE
The evidence is only as good as the team that generates it.
Collaboration
The best evidence comes from people who ask the right questions together. We share what we know and build on each other's work.
Honesty
We tell partners when the evidence doesn't support their program. The same directness applies internally. Difficult conversations happen early, not late.
Accountability
Our work informs decisions that carry real consequences for patients and capital. We own that.
Excellence
We hold ourselves to the standard of evidence that could be trusted at a Board of Director-level decisions. Not because it's expected. Because that's the point.